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1

Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice

Sayaka Kato, Yukio Kato, Tadakatsu Nakamura, Tomoko Sugiura, Yoshiyuki Kubo, Yoshiharu Deguchi, Akira Tsuji

Journal:

Biopharmaceutics & Drug Disposition

Year:

2009

Language:

english

File:

PDF, 170 KB

english, 2009

2

Degradation kinetics and mechanism of aminocephalosporins in aqueous solution: Cefadroxil

Akira Tsuji, Emi Nakashima, Yoshiharu Deguchi, Kazunori Nishide, Takayoshi Shimizu, Sumio Horiuchi, Kiyoyasu Ishikawa, Tsukinaka Yamana

Journal:

Journal of Pharmaceutical Sciences

Year:

1981

Language:

english

File:

PDF, 909 KB

english, 1981

3

Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model

Higuchi, Kei, Kitamura, Atsushi, Okura, Takashi, Deguchi, Yoshiharu

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2015

Language:

english

File:

PDF, 889 KB

english, 2015

4

Structure analyses using X-ray photoelectron spectroscopy and X-ray absorption near edge structure for amorphous MS3 (M: Ti, Mo) electrodes in all-solid-state lithium batteries

Matsuyama, Takuya, Deguchi, Minako, Mitsuhara, Kei, Ohta, Toshiaki, Mori, Takuya, Orikasa, Yuki, Uchimoto, Yoshiharu, Kowada, Yoshiyuki, Hayashi, Akitoshi, Tatsumisago, Masahiro

Journal:

Journal of Power Sources

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

5

Laparoscopic left hemicolectomy with regional lymph node navigation and intracorporeal anastomosis for splenic flexure colon cancer

Itatani, Yoshiro, Kawada, Kenji, Hida, Koya, Deguchi, Yasunori, Oshima, Nobu, Mizuno, Rei, Wada, Toshiaki, Okada, Tomoaki, Sakai, Yoshiharu

Journal:

International Cancer Conference Journal

Year:

2020

File:

PDF, 999 KB

2020

6

Drug–drug interaction between oxycodone and adjuvant analgesics in blood–brain barrier transport and antinociceptive effect

Yusuke Nakazawa, Takashi Okura, Keita Shimomura, Tetsuya Terasaki, Yoshiharu Deguchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 228 KB

english, 2010

7

Diphenhydramine active uptake at the blood–brain barrier and its interaction with oxycodone in vitro and in vivo

Muhammad Waqas Sadiq, Annika Borgs, Takashi Okura, Keita Shimomura, Sayaka Kato, Yoshiharu Deguchi, Britt Jansson, Sven Björkman, Tetsuya Terasaki, Margareta Hammarlund-udenaes

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 786 KB

english, 2011

8

Functional characterization of rat plasma membrane monoamine transporter in the blood–brain and blood–cerebrospinal fluid barriers

Takashi Okura, Sayaka Kato, Yusuke Takano, Takenori Sato, Atsushi Yamashita, Riyo Morimoto, Sumio Ohtsuki, Tetsuya Terasaki, Yoshiharu Deguchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 606 KB

english, 2011

9

Kinetics of peritoneal drug transport in rats: An application of the pore theory of transcapillary exchange

Emi Nakashima, Fusashi Ishikawa, Hitoshi Sato, Yoshiharu Deguchi, Ikumi Tamai, Ryo Matsushita, Fujio Ichimura, Akira Tsuji

Journal:

Journal of Pharmaceutical Sciences

Year:

1988

Language:

english

File:

PDF, 848 KB

english, 1988

10

Peritoneal transport of β-lactam antibiotics: Effects of plasma protein binding and the interspecies relationship

Yoshiharu Deguchi, Emi Nakashima, Fusashi Ishikawa, Hitoshi Sato, Ikumi Tamai, Ryo Matsushita, Yohei Tofuku, Fujio Ichimura, Akira Tsuji

Journal:

Journal of Pharmaceutical Sciences

Year:

1988

Language:

english

File:

PDF, 645 KB

english, 1988

11

Interindividual changes in volume of distribution of cefazolin in newborn infants and its prediction based on physiological pharmacokinetic concepts

Yoshiharu Deguchi, Rie Koshida, Emi Nakashima, Reiji Watanabe, Noboru Taniguchi, Fujio Ichimura, Akira Tsuji

Journal:

Journal of Pharmaceutical Sciences

Year:

1988

Language:

english

File:

PDF, 521 KB

english, 1988

12

Mutual interaction between bilirubin and cefazolin in binding to human serum albumin

Fujio Ichimura, Ryo Matsushita, Akira Tsuji, Yoshiharu Deguchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1990

Language:

english

File:

PDF, 251 KB

english, 1990

13

Internalization of basic fibroblast growth factor at the mouse blood–brain barrier involves perlecan, a heparan sulfate proteoglycan

Yoshiharu Deguchi, Hiroshi Okutsu, Takashi Okura, Shizuo Yamada, Ryohei Kimura, Takuro Yuge, Akihiko Furukawa, Kazuhiro Morimoto, Masanori Tachikawa, Sumio Ohtsuki, Ken-ichi Hosoya, Tetsuya Terasaki

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 449 KB

english, 2002

14

Blood–brain barrier transport of a novel µ1-specific opioid peptide, H-Tyr-d-Arg-Phe-β-Ala-OH (TAPA)

Yoshiharu Deguchi, Yusaku Miyakawa, Shinobu Sakurada, Yu Naito, Kazuhiro Morimoto, Sumio Ohtsuki, Ken-ichi Hosoya, Tetsuya Terasaki

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 145 KB

english, 2003

15

Synthesis of polyglactin by melt/solid polycondensation of glycolic/L-lactic acids

Sung-Il Moon, Kenji Deguchi, Masatoshi Miyamoto, Yoshiharu Kimura

Journal:

Polymer International

Year:

2004

Language:

english

File:

PDF, 98 KB

english, 2004

16

Pharmacokinetic and pharmacological interactions between ticlopidine hydrochloride and Kangen-Karyu – Chinese traditional herbal medicine

Toshiaki Makino, Hannosuke Wakushima, Takuya Okamoto, Yasuhiro Okukubo, Yoshiharu Deguchi, Yoshihiro Kano

Journal:

Phytotherapy Research

Year:

2003

Language:

english

File:

PDF, 140 KB

english, 2003

17

In Vivo Specific Binding Characteristics and Pharmacokinetics of a 1,4-Dihydropyridine Calcium Channel Antagonist in the Senescent Mouse Brain

Shinya Uchida, Shizuo Yamada, Yoshiharu Deguchi, Minoru Yamamoto, Ryohei Kimura

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

18

Blood-Brain Barrier Transport of 125I-Labeled Basic Fibroblast Growth Factor

Yoshiharu Deguchi, Takafumi Naito, Takuro Yuge, Akihiko Furukawa, Shizuo Yamada, William M. Pardridge, Ryohei Kimura

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 428 KB

english, 2000

19

In VivoTransport of a Dynorphin-like Analgesic Peptide, E-2078, Through the Blood–Brain Barrier: An Application of Brain Microdialysis

Tetsuya Terasaki, Yoshiharu Deguchi, Hitoshi Sato, Ken-ichi Hirai, Akira Tsuji

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 1.13 MB

1991

20

Study on Brain Interstitial Fluid Distribution and Blood-Brain Barrier Transport of Baclofen in Rats by Microdialysis

Yoshiharu Deguchi, Kazimori Inabe, Koichi Tomiyasu, Kenji Nozawa, Shizuo Yamada, Ryohei Kimura

Journal:

Pharmaceutical Research

Year:

1995

File:

PDF, 1.33 MB

1995

21

Aminated gelatin as a nasal absorption enhancer for peptide drugs: evaluation of absorption enhancing effect and nasal mucosa perturbation in rats

Jian Wang, Shigeko Sakai, Yoshiharu Deguchi, Dianzhou Bi, Yasuhiko Tabata, Kazuhiro Morimoto

Journal:

Journal of Pharmacy and Pharmacology

Year:

2002

Language:

english

File:

PDF, 217 KB

english, 2002

22

Studies on the transport of thyrotropin-releasing hormone (TRH) analogues in Caco-2 cell monolayers

Akihiko Urayama, Shizuo Yamada, Yoshiharu Deguchi, Yuki Ohmori, Ryohei Kimura

Journal:

Journal of Pharmacy and Pharmacology

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

23

Determination of in vivo steady-state unbound drug concentration in the brain interstitial fluid by microdialysis

Terasaki Tetsuya, Deguchi Yoshiharu, Kasama Yuko, William M. Pardridge, Tsuji Akira

Journal:

International Journal of Pharmaceutics

Year:

1992

Language:

english

File:

PDF, 943 KB

english, 1992

24

Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent

Masahide Odan, Natsuki Ishizuka, Yoshiharu Hiramatsu, Masanao Inagaki, Hiroshi Hashizume, Yasuhiko Fujii, Susumu Mitsumori, Yasuhide Morioka, Masahiko Soga, Masashi Deguchi, Kiyoshi Yasui, Akinori Ari

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 719 KB

english, 2012

25

Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent

Masahide Odan, Natsuki Ishizuka, Yoshiharu Hiramatsu, Masanao Inagaki, Hiroshi Hashizume, Yasuhiko Fujii, Susumu Mitsumori, Yasuhide Morioka, Masahiko Soga, Masashi Deguchi, Kiyoshi Yasui, Akinori Ari

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

26

CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: Reduction of CNS side effects by introducing polar functional groups

Masahide Odan, Natsuki Ishizuka, Yoshiharu Hiramatsu, Masanao Inagaki, Hiroshi Hashizume, Yasuhiko Fujii, Susumu Mitsumori, Yasuhide Morioka, Masahiko Soga, Masashi Deguchi, Kiyoshi Yasui, Akinori Ari

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.21 MB

english, 2012

27

In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier

Atsushi Sakata, Ikumi Tamai, Kouichi Kawazu, Yoshiharu Deguchi, Toshimasa Ohnishi, Akira Saheki, Akira Tsuji

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 488 KB

english, 1994

28

Distribution characteristics of orally administered olamufloxacin, a newly synthesized fluoroquinolone antibacterial, in lung epithelial lining fluid and alveolar macrophage in rats

Jin Sun, Yoshiharu Deguchi, Yoshihiko Tauchi, Zhonggui He, Gang Cheng, Kazuhiro Morimoto

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2006

Language:

english

File:

PDF, 223 KB

english, 2006

29

Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6β-glucuronide in rats

Takashi Okura, Noriyuki Komiyama, Yuki Morita, Midori Kimura, Yoshiharu Deguchi, Shizuo Yamada

Journal:

Year:

2007

Language:

english

File:

PDF, 362 KB

english, 2007

30

Blood–brain barrier transport of pramipexole, a dopamine D2 agonist

Takashi Okura, Rie Ito, Naoki Ishiguro, Ikumi Tamai, Yoshiharu Deguchi

Journal:

Year:

2007

Language:

english

File:

PDF, 403 KB

english, 2007

31

Brain receptor binding characteristics and pharmacokinetic-pharmacodynamic analysis of thyrotropin-releasing hormone analogues

Akihiko Urayama, Shizuo Yamada, Kazufumi Hirano, Yoshiharu Deguchi, Ryohei Kimura

Journal:

Year:

2001

Language:

english

File:

PDF, 108 KB

english, 2001

32

Brain pharmacokinetics and in vivo receptor binding of 1,4-dihydropyridine calcium channel antagonists

Shinya Uchida, Shizuo Yamada, Kenji Nagai, Yoshiharu Deguchi, Ryohei Kimura

Journal:

Year:

1997

Language:

english

File:

PDF, 758 KB

english, 1997

33

Ex vivo occupancy by tamsulosin of α1-adrenoceptors in rat tissues in relation to the plasma concentration

Takashi Ohkura, Shizuo Yamada, Yoshiharu Deguchi, Ryohei Kimura, Hiroshi Matsushima, Saburo Higuchi, Osamu Inagaki, Kazuo Honda, Toichi Takenaka

Journal:

Year:

1998

Language:

english

File:

PDF, 807 KB

english, 1998

34

Brain receptor binding characteristics and pharmacokinetics of JTP-2942, a novel thyrotropin-releasing hormone (TRH) analogue

Akihiko Urayama, Shizuo Yamada, Yoshiharu Deguchi, Ryohei Kimura, Yuki Maeda, Takuo Kobayashi

Journal:

Year:

1999

Language:

english

File:

PDF, 784 KB

english, 1999

35

Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier 1

Yoshiharu Deguchi, Yoshinari Yokoyama, Tatsuichiro Sakamoto, Hideki Hayashi, Takafumi Naito, Shizuo Yamada, Ryohei Kimura

Journal:

Year:

2000

Language:

english

File:

PDF, 1003 KB

english, 2000

36

Pharmacokinetic interactions between warfarin and kangen-karyu, a Chinese traditional herbal medicine, and their synergistic action

Toshiaki Makino, Hannosuke Wakushima, Takuya Okamoto, Yasuhiro Okukubo, Yoshiharu Deguchi, Yoshihiro Kano

Journal:

Journal of Ethnopharmacology

Year:

2002

Language:

english

File:

PDF, 173 KB

english, 2002

37

Determination of lipophilicity of two quinolone antibacterials, ciprofloxacin and grepafloxacin, in the protonation equilibrium

Jin Sun, Shigeko Sakai, Yoshihiko Tauchi, Yoshiharu Deguchi, Jimin Chen, Ruhua Zhang, Kazuhiro Morimoto

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2002

Language:

english

File:

PDF, 166 KB

english, 2002

38

Protonation equilibrium and lipophilicity of olamufloxacin (HSR-903), a newly synthesized fluoroquinolone antibacterial

Jin Sun, Shigeko Sakai, Yoshihiko Tauchi, Yoshiharu Deguchi, Gang Cheng, Jimin Chen, Kazuhiro Morimoto

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2003

Language:

english

File:

PDF, 235 KB

english, 2003

39

Characterization of the carrier-mediated transport of ketoprofen, a nonsteroidal anti-inflammatory drug, in rabbit corneal epithelium cells

Shinobu Fujii, Hideki Hayashi, Kunihiko Itoh, Shizuo Yamada, Yoshiharu Deguchi, Kouichi Kawazu

Journal:

Journal of Pharmacy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 781 KB

english, 2012

40

Efficient drug delivery to atherosclerotic lesions and the antiatherosclerotic effect by dexamethasone incorporated into liposomes in atherogenic mice

Chono, Sumio, Tauchi, Yoshihiko, Deguchi, Yoshiharu, Morimoto, Kazuhiro

Journal:

Journal of Drug Targeting

Year:

2005

Language:

english

File:

PDF, 230 KB

english, 2005

41

Ependymal cells of the mouse brain express urate transporter 1 (URAT1)

Tomioka, Naoko H, Nakamura, Makiko, Doshi, Masaru, Deguchi, Yoshiharu, Ichida, Kimiyoshi, Morisaki, Takayuki, Hosoyamada, Makoto

Journal:

Fluids and Barriers of the CNS

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

42

Hydroxychloroquine/oxycodone/paracetamol overdose

Tomioka, Naoko H, Nakamura, Makiko, Doshi, Masaru, Deguchi, Yoshiharu, Ichida, Kimiyoshi, Morisaki, Takayuki, Hosoyamada, Makoto

Journal:

Reactions Weekly

Year:

2013

Language:

english

File:

PDF, 128 KB

english, 2013

43

Fluorouracil/lisinopril interaction

Tomioka, Naoko H, Nakamura, Makiko, Doshi, Masaru, Deguchi, Yoshiharu, Ichida, Kimiyoshi, Morisaki, Takayuki, Hosoyamada, Makoto

Journal:

Reactions Weekly

Year:

2013

Language:

english

File:

PDF, 128 KB

english, 2013

44

Physiologically based pharmacokinetics of valproic acid in rabbits

Ichimura, Fujio, Deguchi, Yoshiharu, Yokogawa, Koichi, Yamana, Tsukinaka

Journal:

International Journal of Pharmaceutics

Year:

1985

Language:

english

File:

PDF, 881 KB

english, 1985

45

Retention of Biologic Activity of Human Epidermal Growth Factor Following Conjugation to a Blood-Brain Barrier Drug Delivery Vector via an Extended Poly(ethylene glycol) Linker

Deguchi, Yoshiharu, Kurihara, Atsushi, Pardridge, William M.

Journal:

Bioconjugate Chemistry

Year:

1999

Language:

english

File:

PDF, 85 KB

english, 1999

46

Transport Characteristics of Tramadol in the Blood-Brain Barrier

Kitamura, Atsushi, Higuchi, Kei, Okura, Takashi, Deguchi, Yoshiharu

Journal:

Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 1.48 MB

english, 2014

47

Synthesis of poly- and oligo(hydroxyalkanoate)s by deep-sea bacteria, Colwellia spp., Moritella spp., and Shewanella spp

Numata, Keiji, Morisaki, Kumiko, Tomizawa, Satoshi, Ohtani, Misato, Demura, Taku, Miyazaki, Masayuki, Nogi, Yuichi, Deguchi, Shigeru, Doi, Yoshiharu

Journal:

Polymer Journal

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

48

Improved Brain Delivery of a Nonsteroidal Anti-Inflammatory Drug with a Synthetic Glyceride Ester: a Preliminary Attempt at a CNS Drug Delivery System for the Therapy of Alzheimer's Disease

Deguchi, Yoshiharu, Hayashi, Hideki, Fujii, Shinobu, Naito, Takafumi, Yokoyama, Yoshinari, Yamada, Shizuo, Kimura, Ryohei

Journal:

Journal of Drug Targeting

Year:

2000

Language:

english

File:

PDF, 805 KB

english, 2000

49

Application of In Vivo Brain Microdialysis to the Study of Blood-brain Barrier Transport of Drugs

Deguchi, Yoshiharu

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2002

Language:

english

File:

PDF, 287 KB

english, 2002

50

Distribution Characteristics of Grepafloxacin, a Fluoroquinolone Antibiotic, in Lung Epithelial Lining Fluid and Alveolar Macrophage

Deguchi, Yoshiharu, Sun, Jin, Tauchi, Yoshihiko, Sakai, Shigeko, Morimoto, Kazuhiro

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2003

Language:

english

File:

PDF, 216 KB

english, 2003